![]() This thematic series aims to highlight the pros and cons of adult stem cell therapies as related to visual disorders and describe the state of the art. Although some early clinical trials have been successful with MSC, the growing popularity of stem-cell clinics in the USA muddied the waters with controversial outcomes of these therapeutics, raising concerns among the public. Recent advances in generating induced pluripotent stem cells (iPSC) from somatic cells have opened up a new avenue of possibilities, including the generation of retinal organoids that likely provide a platform to better understand the disease mechanism with an added advantage to provide preclinical testing of new treatments. Parkinsons Disease Alzheimers Disease Heart Diseases, Stroke and Diabetes (Type 1) Birth Defects Spinal Cord Injuries Replace or Repair Damaged Organs. A variety of adult stem cells, including but not limited to hematopoietic stem cells (HSC), mesenchymal stem cells (MSC), especially those derived from adipose tissue and bone marrow, and endothelial progenitor cells (EPC), have been explored as a possible treatment for retinal diseases with excellent efficacy in preclinical models. ISCs (marked by Dl) could self-renew and generate 2 types of committed progenitors EBs (marked by Su(H) and Klu) and EEPs (marked by low levels of both Dl and Pros). a) A schematic for the ISC lineage in adult Drosophila midgut. Guest edited by Rajashekhar Gangaraju, The University of Tennessee Health Science Center, USAĪ thematic series in Stem Cell Research & Therapy.Īdult stem cells found throughout the body are now known to replenish dying cells and regenerate damaged tissues. Polo was specifically expressed in progenitor cells and showed a dynamic distribution during mitosis. One of the main benefits of adult stem cells is that they can be obtained from the patients own body, reducing the risk of rejection by the immune system and increasing the chances of success of the treatment.
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